Publications by authors named "Krittisak Chaiyakul"
Article Synopsis
- The amino acid isoleucine plays a significant role in metabolic health, with lower dietary levels linked to improved health in mice on a Western Diet.
- The effects of isoleucine reduction vary by sex and strain in mice, showing a protective benefit against metabolic issues, while its increase can worsen health.
- Findings reveal that a core molecular response to dietary isoleucine exists across different sexes and strains, highlighting its potential as a dietary strategy for better metabolic health in humans.
Article Synopsis
- - Low-protein diets enhance health and lifespan across different species, with specific emphasis on the benefits of restricting branched-chain amino acids (BCAAs) in mice.
- - A study showed that a restriction of isoleucine (IleR) led to improved metabolic health, promoting leanness and better blood sugar control in both young and old genetically diverse UM-HET3 mice.
- - IleR not only reduced frailty but also extended the lifespan of mice, especially in males, indicating its potential as a geroprotective strategy either through dietary changes or drugs that mimic its effects.
Low-protein diets promote metabolic health in humans and rodents. Despite evidence that sex and genetic background are key factors in the response to diet, most protein intake studies examine only a single strain and sex of mice. Using multiple strains and both sexes of mice, we find that improvements in metabolic health in response to reduced dietary protein strongly depend on sex and strain.
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