Publications by authors named "Kritika Sood"
Article Synopsis
- Open nanoshells, or 'semi shells', have special plasmonic properties due to their asymmetric structure and are typically made using complex methods, but this study introduces a simpler one-step process for creating them.
- The newly fabricated PEGylated semi-shells show strong localized surface plasmon resonance under near-infrared light and remain effective even after being preserved for long periods, demonstrating safety in mice with no toxic effects post intravenous injection.
- In animal trials, these PEGylated semi-shells exhibited high photothermal efficiency, leading to complete eradication of primary breast tumors without affecting critical organs, and resulted in a 75% survival rate without complications for up to 90 days
Autologous serum protein stabilized silver quantum clusters as host-specific antibacterial agents.
Nanomedicine (Lond)
September 2024
Article Synopsis
- The study aimed to create silver quantum clusters stabilized by serum proteins from different hosts (bovine, human, and murine) to evaluate their safety and effectiveness as antibacterial agents.
- Ag-QCNS showed strong antibacterial properties, particularly against antibiotic-resistant strains, and demonstrated high biocompatibility and hemocompatibility in preclinical tests with mice over a 28-day period.
- The antibacterial mechanism involved the generation of reactive oxygen species (ROS) and damage to bacterial membranes, suggesting that Ag-QCNS could serve as a promising next-generation treatment option for antibiotic resistance.
Core-shell nanostructures of silicon oxide@noble metal have drawn a lot of interest due to their distinctive characteristics and minimal toxicity with remarkable biocompatibility. Due to the unique property of localized surface plasmon resonance (LSPR), plasmonic nanoparticles are being used as surface-enhanced Raman scattering (SERS) based detection of pollutants and photothermal (PT) agents in cancer therapy. Herein, we demonstrate the synthesis of multifunctional silica core - Au nanostars shell (SiO @Au NSs) nanostructures using surfactant free aqueous phase method.
View Article and Find Full Text PDFHost derived serum proteome stabilised red-emitting gold quantum clusters (or Au-QC-NanoSera or QCNS) of size range ~2 nm have been synthesised in a first reported study. The host serum was taken from bovine, murine and human origins to establish the proof of concept. biocompatibility with normal murine L929 fibroblast cells and radiosensitisation ability against PLC/PRF/5 hepatoma cells was established.
View Article and Find Full Text PDFFor the first time, PdP has been synthesised using a simple, straightforward and one-pot method , thermolysis of a Pd(II) complex of a bidentate (P, N) organophosphorus ligand (anthracene-9-yl-CHN-CHCH-PPh). The electrocatalyst (obtained after grafting nanospheres of PdP over layers of graphene oxide) shows high activity in electrochemical hydrogen evolution reactions (HER) with an overpotential of 133 mV to drive 10 mA cm of cathodic current density. The GO-PdP nanocomposite is robust and effective for a continuous HER run for up to 16 hours.
View Article and Find Full Text PDFEngineered nanomaterials consisting of multiple nanoparticles (NPs) are finding their use in fields as wide and diverse as medicine, environment, cosmetics, energy and electronics. However, health and environmental impacts of these NPs need to be discerned individually to understand their true toxicity. Due to the promising application of upcoming material like GO-ZnO nanocomposite, the toxicity of ZnO and GO NPs was evaluated and compared individually in our study.
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