Mechanistic Insights into Cellular and Molecular Targets of Zinc Oxide Quantum Dots (ZnO QDs) in Fungal Pathogen, : One Drug Multi-Targeted Therapeutic Approach.

Rationally designed multitargeted drugs, known as network therapeutics/multimodal drugs, have emerged as versatile therapeutic solutions to combat drug-resistant microbes. Here, we report novel mechanistic insights into cellular and molecular targets of ZnO quantum dots (QDs) against , a representative of fungal pathogens. Stable, monodispersed 4-6 nm ZnO QDs were synthesized using a wet chemical route, which exhibited dose-dependent inhibition on the growth dynamics of .

Rationally designed protein A surface molecularly imprinted magnetic nanoparticles for the capture and detection of .

(), a commensal organism found on the human skin, is commonly associated with nosocomial infections and exhibits virulence mediated by toxins and resistance to antibiotics. The global threat of antibiotic resistance has necessitated antimicrobial stewardship to improve the safe and appropriate use of antimicrobials; hence, there is an urgent demand for the advanced, cost-effective, and rapid detection of specific bacteria. In this regard, we aimed to selectively detect using surface molecularly imprinted magnetic nanoparticles templated with a well-known biomarker protein A, specific to .

A facile cost-effective electrolyte-assisted approach and comparative study towards the Greener synthesis of silica nanoparticles.

Nowadays, silica nanoparticles are gaining tremendous importance because of their wide applications across different domains such as drug delivery, chromatography, biosensors, and chemosensors. The synthesis of silica nanoparticles generally requires a high percentage composition of organic solvent in an alkali medium. The eco-friendly synthesis of silica nanoparticles in bulk amounts can help save the environment and is cost-effective.