Publications by authors named "Kritika Gaur"
Advanced 2D Nanomaterials for Phototheranostics of Breast Cancer: A Paradigm Shift.
Adv Biol (Weinh)
November 2024
Breast cancer is the leading cause of women's deaths and associated comorbidities. The advanced and targeted strategies against breast cancer have gained considerable attention due to their potential enhanced therapeutic efficacy over conventional therapies. In this context, phototherapies like photodynamic therapy (PDT) and photothermal therapy (PTT) have shown promise as an effective and alternative strategy due to reduced side effects, noninvasiveness, and spatiotemporal specificity.
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- PAI-1 (Plasminogen activator inhibitor-1) traditionally functions as a secretory protease inhibitor, playing a role in preventing blood clot breakdown but reportedly has a complex relationship with tumor progression.
- Recent research indicates that PAI-1 also localizes within the cytoplasm and nucleus, suggesting it may have additional unexplored intracellular functions.
- The study reveals that PAI-1 has a nuclear export signal and is found in specific nuclear structures (PML bodies) linked to the growth of endothelial cells, implying its potential connection to aging and cancer development.
Article Synopsis
- * The integration of artificial intelligence (AI), machine learning (ML), and deep learning (DL) into healthcare has shown significant potential in predicting cancer risks and improving survival rates.
- * These technologies enable precise diagnosis and personalized treatment plans, ultimately improving patients' quality of life and transforming cancer care for conditions like diffuse large B-cell lymphoma (DLBCL) and various tumors.