Chemo- and Regioselective Catalytic Cross-Coupling Reaction of Ketones for the Synthesis of β, γ-Disubstituted β, γ-Unsaturated Ketones.

C-C bond forming reaction of ketone with aldehyde is well-studied for the synthesis of α, β-unsaturated ketones, however, the reaction with two different ketones to unsaturated carbonyl compound has not yet been systematically studied. Probably due to the relatively low reactivity of ketones as electrophiles (aldol acceptors), its propensity for retro-aldol reaction. The reactions often suffer from unsatisfactory chemoselectivity (self- vs.