[In vitro methods of transdermal drug absorption: the skin PAMPA model].

The present article summarizes the features of human skin as absorption site and describes a new model for skin penetration prediction. The parallel artificial membrane permeability assay (PAMPA), a high throughput method that serves as the basis of the model is also discussed in details demonstrating its features and published applications. The paper focuses on the steps of model development and on the comparisons to human skin datasets.

[Good laboratory practice of equilibrium solubility measurement III. Dissolution measurements].

In this paper the theoretical background of dissolution determining the oral administration, the physicochemical and physiological factors influencing the rate of dissolution, the relation between solubility and dissolution, the most important pharmacopoeial and miniaturized dissolution measurements and finally the dissolution in biorelevant media are reviewed.

[Pharmaceutical chemistry of minor analgesics and non-steroidal antiinflammatory agents].

The paper represents the last (6th) part of a series about agents acting on the central nervous system. This time the minor analgesics and the non-steroidal antiinflammatory agents are surveyed. As previously, the material is divided into chapters of history, preparation; structure-properties-activity; therapeutical use; analysis.

[Current problems in the quality controll of pharmaceutical preparations manufactured in pharmacies I. Identification tests].

Quality controll has fundamental importance in drug safety. During the last 15 years the regulatory changes resulted many problems in the quality controll of pharmaceutical preparations manufactured in pharmacys. The issue of Formulae Normales (FoNo VII.

[Pharmaceutical chemistry of antidepressive drugs].

The paper represents the 4th part of a series about agents acting on the central nervous system. This time the antidepressants are surveyed. As previously, the material is divided into chapters of hystory, preparation; structure-properties-activity; therapeutical use; analysis.

[Pharmaceutical chemistry of neuroleptic drugs].

The paper represents the 3rd part of a series about agents acting on the central nervous system. This time the neuroleptics are surveyed. As previously, the material is divided into chapters of history, preparation; structure-properties-activity; therapeutical use; analysis.