Lid-parallel conjunctival folds (LIPCOF) and dry eye: a multicentre study.

Aims: The study was designed to test the clinical application of the grading of lid-parallel conjunctival folds (LIPCOF) as a diagnostic test for dry eye.

Methods: At 12 centres in 11 countries, 272 eyes of 272 dry eye patients (75 men, 197 women) were examined. Their mean age was 52.

Increased tear osmolarity in patients with severe cases of conjunctivochalasis.

Purpose: To evaluate and compare tear osmolarity in different grades of conjunctivochalasis.

Patients And Methods: Forty subjects divided into four groups based on grading of conjunctivochalasis by lid-paralell conjunctival fold (LIPCOF) test and tear osmolarity evaluated by TearLab osmometer. Schirmer test, tear film break up time (BUT) and vital staining were also performed.

Tear film function in patients with seasonal allergic conjunctivitis outside the pollen season.

Background: Seasonal allergic conjunctivitis can manifest itself through tear film instability and symptoms of eye discomfort during the pollen season. This study investigated whether seasonal allergic inflammation defines tear film instability outside the season.

Methods: Twenty-three control subjects and 13 ragweed-allergic patients were involved (21 female, 15 male; mean age 26.

OCT Imaging of lid-parallel conjunctival folds in soft contact lens wearers.

Purpose: To visualize, using Fourier-domain optical coherence tomography (FD-OCT), the alterations in lid-parallel conjunctival fold (LIPCOF) morphology in eyes with contact lenses and after their removal.

Methods: One randomly selected eye of each of 24 volunteers with normal ocular surface status was examined using FD-OCT. The study group included 18 female and 6 male subjects, with a mean age of 28.

Imaging lid-parallel conjunctival folds with OCT and comparing its grading with the slit lamp classification in dry eye patients and normal subjects.

Purpose: To visualize and describe the morphologic appearance of lid-parallel conjunctival folds (LIPCOFs) by using optical coherence tomography (OCT) and to relate it to dry eye signs and symptoms.

Methods: The LIPCOF grade, noninvasive tear film breakup time (NIBUT), lipid layer interference pattern, and dry eye symptoms were recorded in 17 normal subjects and 33 patients with dry eye. LIPCOFs were evaluated with a slit lamp and visualized by OCT.

Kinetic analysis of topographical parameters and interference pattern of tear lipid layer in normal subjects.

Purpose: To investigate the post-blink changes of the topographical regularity indices, the corneal wavefront aberrations and the tear lipid layer's interference pattern, and analyze the relationship between these parameters' changes.

Methods: Sequential topographical measurements were recorded on 23 normal participants. The surface regularity index (SRI), surface asymmetry index (SAI), corneal total higher order aberrations (HOA) root mean square (RMS), Coma RMS and Spherical RMS were calculated from the topographical measurement.