Publications by authors named "Kristopher Bakos"
Article Synopsis
- Epidural opioids, such as methadone and morphine, are used for managing acute postoperative pain, but this study investigates whether methadone provides better localized pain relief (segmental analgesia) than morphine.
- In the study, 13 healthy volunteers received epidural injections of either 4 mg of methadone or morphine and their pain tolerance was tested across different body regions for 24 hours.
- Results showed no significant difference in localized pain relief between the two drugs, although morphine resulted in longer-lasting analgesia and more systemic side effects compared to methadone, which had a better side effect profile.
Objectives: Intravenous lidocaine can alleviate painful diabetic peripheral neuropathy (DPN) in some patients. Whether quantitative sensory testing (QST) can identify treatment responders has not been prospectively tested.
Materials And Methods: This was a prospective, randomized, double-blind, crossover, placebo-controlled trial comparing intravenous lidocaine to normal saline (placebo) for painful DPN.
Painful chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and treatment-resistant sequela of many chemotherapeutic medications. Ligands of α2δ subunits of voltage-gated Ca channels, such as pregabalin, have shown efficacy in reducing mechanical sensitivity in animal models of neuropathic pain. In addition, some data suggest that pregabalin may be more efficacious in relieving neuropathic pain in subjects with increased sensitivity to pinprick.
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