Publications by authors named "Kristof Garami"
Photoaffinity labeling is a widely used methodology for interrogating small molecule-protein interactions. However, these applications are limited by the few photo-crosslinkers that typically modify the affinity and the binding mode of the original ligand. Here, we report the development of new target agnostic photoaffinity warheads, sulfohydrazones that form a reactive carbene upon UV irradiation.
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- This study focuses on the synthesis and characterization of π-extended phosphetene rings (4-member P-rings) combined with various polyaromatic hydrocarbon (PAH) systems, analyzing their structural and optical properties.
- Despite the P center and 4-member ring not directly participating in the highest occupied or lowest unoccupied molecular orbitals (HOMO/LUMO), they significantly impact the symmetry and chiroptical properties of the compounds.
- The stereogenic phosphorus atom acts as a chiral influence, enhancing circularly polarized luminescence in the PAH system, which varies significantly with the PAH's topology.