Effective plasma alfaxalone concentration to produce immobility in male neutered cats.

Objective: To determine the effective plasma alfaxalone concentration for the production of immobility in cats.

Study Design: Prospective up-and-down study.

Animals: Sixteen 1-2 year old male castrated research cats.

Hemodynamic effects of dexmedetomidine, with and without MK-467, following intramuscular administration in cats anesthetized with isoflurane.

Objective: To characterize the hemodynamic effects of dexmedetomidine, with or without MK-467, following intramuscular (IM) administration in cats.

Study Design: Randomized, crossover, experimental study.

Animals: Six healthy adult male castrated purpose-bred cats.

Pharmacokinetics of dexmedetomidine administered intravenously in isoflurane-anesthetized cats.

Objective: To determine the pharmacokinetics of dexmedetomidine administered as a short-duration IV infusion in isoflurane-anesthetized cats.

Animals: 6 healthy adult domestic female cats.

Procedures: Dexmedetomidine hydrochloride was injected IV (10 μg/kg over 5 minutes [rate, 2 μg/kg/min]) in isoflurane-anesthetized cats.

Thermal antinociceptive effect of orally administered gabapentin in healthy cats.

Objective: To determine the thermal antinociceptive effect of various single doses of gabapentin administered orally in cats.

Animals: 6 healthy adult domestic shorthair cats.

Procedures: Baseline skin temperature and baseline thermal threshold were determined via application of a thermal probe to the thorax of each cat prior to oral administration (in random order) of an empty capsule (placebo) or a capsule containing 5, 10, or 30 mg of gabapentin/kg (4 experiments/cat).

Pharmacokinetics of gabapentin in cats.

Objective: To determine the pharmacokinetics of gabapentin in cats after IV and oral administration.

Animals: 6 healthy female adult domestic shorthair cats.

Procedures: Gabapentin was administered IV (4 mg/kg) or orally (10 mg/kg) in a crossover randomized design.

Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure.

Objective: To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure.

Animals: 23 dogs treated with a tibial plateau leveling osteotomy.

Procedures: 12 dogs were used as a control group.

Effects of tramadol hydrochloride on the thermal threshold in cats.

OBJECTIVE-To determine the thermal antinociceptive effect of oral administration of tramadol hydrochloride at doses between 0.5 and 4 mg/kg in cats. ANIMALS-6 healthy adult domestic shorthair cats.

Effects of remifentanil on measures of anesthetic immobility and analgesia in cats.

Objective: To evaluate effects of various doses of remifentanil on measures of analgesia in anesthetized cats.

Animals: 6 healthy adult cats.

Procedures: Minimum alveolar concentration (MAC) for isoflurane and thermal threshold responses were evaluated in anesthetized cats.

Effects of epidurally administered morphine or buprenorphine on the thermal threshold in cats.

Objective: To determine the antinociceptive effects of epidural administration of morphine or buprenorphine in cats by use of a thermal threshold model.

Animals: 6 healthy adult cats.

Procedures: Baseline thermal threshold was determined in duplicate.

Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane.

Objective: To characterize the pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane.

Animals: 6 cats.

Procedures: Remifentanil (1 microg/kg/min for 5 minutes) was administered IV in conscious cats or cats anesthetized with 1.