Publications by authors named "Kristine Hommel"
Article Synopsis
- * Although generally safe, reports indicate acute kidney impairment can occur, particularly in patients with cancer or preexisting kidney issues after high doses.
- * This report presents two cases of low-risk patients who developed severe kidney impairment requiring dialysis after a single dose of zoledronic acid, emphasizing the importance of monitoring kidney function in all recipients of the drug.
Article Synopsis
- Cancer can lead to serious kidney issues in children requiring kidney replacement therapy (KRT), with a study identifying 287 pediatric KRT patients who had a history of cancer.
- The study showed that those whose cancer caused KRT had a longer wait for kidney transplantation compared to matched controls, with a median time of 2.4 years for cancer patients versus shorter times for controls.
- While childhood cancer survivors experienced increased mortality rates while on KRT (16% for group 1 and 23% for group 2) compared to controls, their long-term survival rates after kidney transplantation were similar to non-cancer patients.
Background: Inherited kidney diseases (IKD) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease (PRD) category 'miscellaneous' or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic kidney disease) and may negatively influence the use of genetic testing, which may identify a cause for IKDs and some CAKUT.
Methods: We have re-examined the etiology of KRT by composing a separate IKD and CAKUT PRD group using data from the European Renal Association (ERA) Registry.
Background And Hypothesis: Young adults starting kidney replacement therapy (KRT) during childhood and reaching their 18th birthday (i.e. adult survivors of childhood KRT) form a challenging population of interest to nephrologists treating adults, as during this period there will be a transition to adult renal centres.
View Article and Find Full Text PDFBackground: This study validates the application of Systematized Nomenclature of Medicine second edition (SNOMED II) codes used to describe medical kidney biopsies in Denmark in encoded form, aiming to support robust epidemiological research on the causes, treatments and prognosis of kidney diseases.
Methods: Kidney biopsy reports from 1 January 1998 to 31 December 2018 were randomly extracted from the Danish National Patobank, using SNOMED codes. A 5% sample was selected, and nephrologists assessed the corresponding medical records, assigning each case the applied clinical diagnoses.
Background: In 2020, the coronavirus disease 2019 (COVID-19) pandemic caused disruptions in kidney replacement therapy (KRT) services worldwide. The aim of this study was to assess the effect of the COVID-19 pandemic in 2020 on the incidence of KRT, kidney transplantation activity, mortality and prevalence of KRT across Europe.
Methods: Patients receiving KRT were included from 17 countries providing data to the European Renal Association Registry.
Background: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities.
Methods: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data.
Background: This paper compares the most recent data on the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT from Europe to those from the United States (US), including comparisons of treatment modalities (haemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KTx)).
Methods: Data were derived from the annual reports of the European Renal Association (ERA) Registry and the United States Renal Data System (USRDS). The European data include information from national and regional renal registries providing the ERA Registry with individual patient data.
Article Synopsis
- Primary glomerular disease (PGD) is a leading factor in end-stage kidney disease (ESKD), prompting the need for kidney replacement therapy (KRT), with the study analyzing trends in KRT incidence and patient outcomes across Europe from 2000 to 2019.
- The study included data from nearly 70,000 patients, revealing an average incidence of 16.6 per million, with significant variations across countries, and identifying immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) as the most common types.
- Findings showed that while overall incidence declined initially, it stabilized after 2013, and patient survival rates varied among PGD subgroups,
Background: Data on comorbidities in children on kidney replacement therapy (KRT) are scarce. Considering their high relevance for prognosis and treatment, this study aims to analyse the prevalence and implications of comorbidities in European children on KRT.
Methods: We included data from patients <20 years of age when commencing KRT from 2007 to 2017 from 22 European countries within the European Society of Paediatric Nephrology/European Renal Association Registry.
Article Synopsis
- - The study analyzed kidney transplantation (KT) trends across 40 European countries from 2010 to 2018, focusing on total, deceased donor (DD), and living donor (LD) rates using data from the ERA Registry and GODT databases.
- - Overall, the total KT rate rose by 1.9% annually, with increases in both DD-KT (3.4 p.m.p.) and LD-KT (1.5 p.m.p.), but significant variations were noted among different countries, particularly between East and West Europe.
- - By 2018, Spain reported the highest DD-KT rate at 64.6 p.m.p., while Turkey had the highest LD-KT rate at
Article Synopsis
- A study analyzing national data in Denmark found that patients aged 50 and older who experienced acute kidney injury (AKI) during hospital admissions have a higher risk of cardiovascular events or death within a year.
- AKI was identified in 7.0% of admissions, leading to a 1.33 to 1.43 times increased risk of cardiovascular outcomes depending on renal function levels.
- The results held consistent across various age groups and stages of AKI, establishing a clear link between AKI and increased cardiovascular risk among this patient population.
Article Synopsis
- Recent advancements in treating heart attacks, strokes, and pulmonary embolisms have reduced cardiovascular deaths in the general population, but it's unclear if dialysis patients have benefited similarly.
- The study analyzed mortality rates from these conditions in over 220,000 dialysis patients across Europe from 1998 to 2015, comparing results with the general population.
- Findings showed that mortality rates for myocardial infarction, stroke, and pulmonary embolism decreased significantly among dialysis patients over the study periods, indicating some improvements in outcomes for this group.
Background: Data on renal replacement therapy (RRT) for end-stage renal disease were collected by the European Renal Association (ERA) Registry via national and regional renal registries in Europe and countries bordering the Mediterranean Sea. This article provides a summary of the 2019 ERA Registry Annual Report, including data from 34 countries and additional age comparisons.
Methods: Individual patient data for 2019 were provided by 35 registries and aggregated data by 17 registries.
Rationale & Objective: There is a dearth of data characterizing patients receiving kidney replacement therapy (KRT) for kidney failure due to systemic lupus erythematosus (SLE) and their clinical outcomes. The aim of this study was to describe trends in incidence and prevalence of KRT among these patients as well as to compare their outcomes versus those of patients treated with KRT for diseases other than SLE.
Study Design: Retrospective cohort study based on kidney registry data.
Article Synopsis
- Acute kidney injury (AKI) significantly increases the one-year risk of cardiovascular events or death in patients aged 50 and older, regardless of renal function.
- In a study analyzing over 565,000 hospital admissions in Denmark from 2008-2018, 7% of patients experienced AKI, and those with AKI had an increased risk of heart disease, heart failure, or stroke.
- The risk associated with AKI varied according to the patient's estimated glomerular filtration rate (eGFR), showing particularly higher risks in patients with higher eGFR levels.
Background: Patients treated with dialysis or living with a kidney transplant (kidney replacement therapy, KRT) have an increased risk of bone fracture. Patients with diabetes also have an increased risk of fracture. The aim of this study was to investigate whether the presence of diabetes in patients on KRT aggravates the risk of fracture.
View Article and Find Full Text PDFBackground: The European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry collects data on kidney replacement therapy (KRT) via national and regional renal registries in Europe and countries bordering the Mediterranean Sea. This article summarizes the 2018 ERA-EDTA Registry Annual Report, and describes the epidemiology of KRT for kidney failure in 34 countries.
Methods: Individual patient data on patients undergoing KRT in 2018 were provided by 34 national or regional renal registries and aggregated data by 17 registries.
The aims of this study were to determine the frequency of dialysis and kidney transplantation and to estimate the regularity of comprehensive conservative management (CCM) for patients with kidney failure in Europe. This study uses data from the ERA-EDTA Registry. Additionally, our study included supplemental data from Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia and additional data from Israel, Italy, Slovakia using other information sources.
View Article and Find Full Text PDFArticle Synopsis
- A recent study raised concerns about Metformin potentially contributing to acute kidney injury (AKI) despite its known renoprotective effects, leading researchers to investigate its association with AKI in patients with acute infections.
- Using data from a Danish nationwide case-control study from 2008 to 2018, researchers analyzed 46,811 type 2 diabetes patients, comparing those who developed AKI to those who didn't based on their use of different antidiabetics.
- Results indicated that while Metformin was associated with a higher odds ratio for AKI, it wasn't independently responsible since other antidiabetics showed similar associations, suggesting that underlying health conditions may have influenced the outcomes.
Background: This article presents a summary of the 2017 Annual Report of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry and describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 37 countries.
Methods: The ERA-EDTA Registry received individual patient data on patients undergoing RRT for ESRD in 2017 from 32 national or regional renal registries and aggregated data from 21 registries. The incidence and prevalence of RRT, kidney transplantation activity and survival probabilities of these patients were calculated.
Objective: Abrupt decline in renal function following initiation of renin-angiotensin system inhibitor is associated with increased risk of cardiovascular disease, but studies of other antihypertensive drugs are sparse. We investigated the risk of cardiovascular event associated with increased plasma creatinine after initiating first-line antihypertensive treatment.
Methods: In a nationwide cohort study, we identified adult Danish primary care patients initiating either renin-angiotensin system inhibitor, calcium channel blocker or thiazide, between 2008 and mid-2018.
Recent guidelines governing anti-diabetic medications increasingly advocate metformin as first-line therapy in all patients with type 2 diabetes. However, metformin could be associated with increased risk of acute kidney injury (AKI), acute dialysis and lactate acidosis in marginal patients. In a retrospective nationwide cohort study, a total of 168 443 drug-naïve patients with type 2 diabetes ≥50 years, initiating treatment with either metformin or sulphonyl in Denmark between 2000 and 2012 were included in this study (70.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed trends in one-year outcomes for patients with dialysis-requiring acute kidney injury (AKI) in Denmark from 2005 to 2012, focusing on end-stage renal disease (ESRD) and mortality rates.
- A total of 13,819 patients were included, revealing that within one year, 7.4% developed ESRD, and 57.2% died, though the rates showed a slight decline over the years studied.
- The adjusted odds ratios indicated that the likelihood of developing ESRD and dying decreased during the 2011-2012 period compared to 2005-2006, demonstrating improved outcomes for AKI patients over the eight years.