Two synthon C10+C3 strategy synthesis of tomato pinworm sex pheromone- (E)-, (Z)-tridec-4-en-1-yl acetates- was illustrated. The iodinated dec-1-yn was successfully applied as a substrate in the synthesis of sex pheromone. The C10-component-1-iododec-1-yne was first obtained by the electrophilic iodination of dec-1-yne in the presence of cadmium (II) acetate.
View Article and Find Full Text PDFThe present study focuses on the iodination of pyrazoles mediated by cadmium (II) acetate. The objects of research were compounds with pyrazole rings substituted by N-propargyl, C, N-alkyl groups. Depending on the molar ratios of the reagents effective ways of obtaining mono- and triiodo-substituted products with the participation of the propargylic fragment in DMSO were elucidated.
View Article and Find Full Text PDFThe exploration of heterocyclic compounds and their fused analogs, featuring key pharmacophore fragments like pyridine, thiophene, pyrimidine, and triazine rings, is pivotal in medicinal chemistry. These compounds possess a wide array of biological activities, making them an intriguing area of study. The quest for new neurotropic drugs among derivatives of these heterocycles with pharmacophore groups remains a significant research challenge.
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