Publications by authors named "Kristine A Buela"
Article Synopsis
- A study using SAMP1/YitFc (SAMP) mice found that IL-33 plays a complex role in inflammatory bowel disease (IBD), showing both harmful and protective effects depending on the context.
- Researchers observed that as IBD progressed, increased eosinophil infiltration and Th2 cytokines correlated with IL-33 levels, suggesting a link to worsening inflammation, which could be reversed by inhibiting eosinophils or IL-33.
- The findings were supported by human data linking IL-33 and eosinophils in IBD patients and indicate that the gut microbiome influences IL-33 activation, suggesting that targeting IL-33 could be a new treatment strategy for IBD.
Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.
Invest Ophthalmol Vis Sci
September 2012
Purpose: The purpose of this study was to evaluate the anti-inflammatory effect of ethyl pyruvate (EP) in a mouse model of lipopolysaccharide (LPS)-induced corneal inflammation.
Methods: LPS was injected intrastromally into the corneas of C57BL/6 mice followed by treatment with a solution of 2.5% EP in 0.