Publications by authors named "Kristina Somersalo"
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecules (ICAMs) facilitates T cell antigen receptor (TCR)-mediated killing. To dissect TCR and LFA-1 contributions, we evaluated cytolytic activity and granule release by cytotoxic T lymphocytes (CTL) as well as intracellular granule redistribution and morphology of CTL stimulated with natural TCR ligand in the presence or absence of LFA-1 engagement. Although other adhesion mechanisms, e.
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- Immunological synapses are structured junctions between T cells and antigen-presenting cells (APCs), featuring a peripheral and central cluster that aid cytotoxic T lymphocytes (CTLs) in targeting and killing cells.
- The study investigated how human CTLs and helper T cells interact with planar bilayers that mimic cellular environments, finding that CTLs can create specific junctions in response to high levels of ICAM-1, essential for effective immune responses.
- Activated CD8(+) T cells demonstrated a significantly higher formation of these junctions compared to CD4(+) T cells, suggesting that abnormalities in this process may influence CTL efficacy and immune response in tissues.