Publications by authors named "Kristina Poss"
Background: In the pre-vaccine era, invasive disease with Haemophilus influenzae, type b (Hib) commonly presented with osteoarticular involvement. Haemophilus influenzae, type a (Hia) sepsis is a rare but emerging problem in recent years. Here, we report a case of sepsis with concomitant osteoarthritis due to Hia that was the presenting infectious disease manifestation of isolated asplenia in a young child.
View Article and Find Full Text PDFArticle Synopsis
- There is a growing library of functionalized non-natural substrates for protein farnesyltransferase (PFTase), which modifies proteins with a specific sequence, allowing for bioconjugation.
- The most common method for these modifications is copper-catalyzed azide-alkyne cycloaddition (CuAAC), but it has limitations due to copper's toxicity in live cells.
- The study introduces trans-cyclooctene geranyl diphosphate, a substrate that is synthesized in six steps and facilitates a safer, bioorthogonal modification process via tetrazine ligation, avoiding the drawbacks of copper-based methods.