Plakoglobin restores tumor suppressor activity of p53 mutant by sequestering the oncogenic potential of β-catenin.

Tumor suppressor/transcription factor p53 is mutated in over 50% of all cancers. Some mutant p53 proteins have not only lost tumor suppressor activities but they also gain oncogenic functions (GOF). One of the most frequently expressed GOF p53 mutants is Arg175His (p53 ) with well-documented roles in cancer development and progression.