Purpose: To characterize a light damage paradigm and establish structural and immunocytochemical measures of acute and protracted light-induced retinal degeneration in the rhodopsin (RHO) T4R dog model of RHO-autosomal dominant retinitis pigmentosa (ADRP).
Methods: Retinal light damage was induced in mutant dogs with a 1-minute exposure to various light intensities (0.1-1.