In vivo confocal microscopic findings in Lisch corneal dystrophy.

Purpose: To describe the in vivo confocal microscopic and clinicopathologic correlations in Lisch corneal dystrophy.

Methods: This is a retrospective case series of 2 patients with Lisch corneal dystrophy. The diagnosis was made based on clinical findings in both cases and was confirmed histopathologically following epithelial debridement in case 1.

Chronic herpes simplex scleritis: characterization of 9 cases of an underrecognized clinical entity.

Purpose: To characterize in detail persistent and recalcitrant infectious scleritis resulting from herpes simplex virus (HSV).

Design: Retrospective and interventional clinical and immunopathologic case series.

Methods: Nine patients with chronic scleral redness, edema, and pain refractory to conventional therapy underwent a scleroconjunctival biopsy for routine histopathologic evaluation and definitive immunodiagnosis for the presence of HSV.

Hemorrhagic complications from glaucoma surgery in patients on anticoagulation therapy or antiplatelet therapy.

Purpose: To determine the incidence of and risk factors for hemorrhagic complications in patients on anticoagulation (ACT) or antiplatelet therapy (APT) having glaucoma surgery.

Design: Retrospective case-control study.

Methods: Medical records of patients who had glaucoma surgery between July 1, 1998 and March 31, 2005 were reviewed.

Sex differences in brain structure in geriatric depression.

Objective: In an exploratory study, authors compared patients with late-life major depression (MDD) and age-matched control subjects to examine sex differences in frontal and orbito-frontal (OFC) regional brain volumes.

Methods: The study sample comprised 41 patients with MDD and 41 controls. Subjects underwent comprehensive neuropsychiatric examinations and magnetic resonance imaging (MRI) scans.

The significance of subsyndromal depression in geriatrics.

Clinically significant non-major depression has been underinvestigated, despite its high prevalence and public health impact. Although there is increasing recognition of the importance of subsyndromal forms of depression, their nosologic boundaries and neurobiologic mechanisms remain largely unknown. This review discusses the literature pertaining to the current concepts, phenomenology, neurobiology, and treatment approaches for geriatric non-major clinically significant depression.

DNA-protein cross-linking via guanine oxidation: dependence upon protein and photosensitizer.

DNA-protein cross-links form when guanine undergoes a 1-electron oxidation in a flash-quench experiment, and the importance of reactive oxygen species, protein, and photosensitizer is examined here. In these experiments, a strong oxidant produced by oxidative quenching of a DNA-bound photosensitizer generates an oxidized guanine base that reacts with protein to form the covalent adduct. These cross-links are cleaved by hot piperidine and are not the result of reactive oxygen species, since neither a hydroxyl radical scavenger (mannitol) nor oxygen affects the yield of DNA-histone cross-linking, as determined via a chloroform extraction assay.