Publications by authors named "Kristina Kirchner"
Article Synopsis
- * A study in the German river Holtemme utilized effect-directed analysis (EDA) to identify the potent antiandrogen 4-methyl-7-diethylaminocoumarin (C47) and its derivatives, revealing C47's potency was over 5.2 times greater than the known antiandrogen flutamide.
- * C47 was detected in concentrations that indicate significant antiandrogenic activity and was shown to disrupt endocrine function in fish, raising concerns about its potential impact on aquatic ecosystems and human exposure due to its presence in consumer products.
Increasing interest in homoacetogenic bacteria for the production of biochemicals and biofuels requisites the development of new genetic tools for these atypical production organisms. An attractive host for the conversion of synthesis gas or electricity into multi-carbon compounds is Clostridium ljungdahlii. So far only limited achievements in modifying this organism towards the production of industrially relevant compounds have been made.
View Article and Find Full Text PDFBioactivity screening studies often face sample amount limitation with respect to the need for reliable, reproducible and quantitative results. Therefore approaches that minimize sample use are needed. Low-volume exposure and chemical dilution procedures were applied in an androgen receptor reporter gene human cell line assay to evaluate environmental contaminants and androgen receptor modulators, which were the agonist 5α-dihydrotestosterone (DHT); and the antagonists flutamide, bisphenol A, 1-hydroxypyrene and triclosan.
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