Allergenicity and cross-reactivity of coconut oil derivatives: A double-blind randomized controlled pilot study.

Background: Counseling of patients with cocamidopropyl betaine (CAPB) allergy is difficult because the cross-reactivity of CAPB with other coconut-derived surfactants, coconut oil, and coconut fatty acids is largely unknown.

Objective: To provide pilot data regarding the cross-reactivity and allergenicity of surfactants derived from coconut oil.

Methods: A randomized double-blind controlled pilot study of 10 control patients and 12 patients previously found to be allergic to CAPB.