Publications by authors named "Kristina Heuck-Knubel"
Article Synopsis
- Glucocorticoid (GC) treatment in embryonic pituitary cells leads to early growth hormone (GH) production, which requires ongoing protein synthesis and involves unique regulatory mechanisms since GH genes lack standard GC response elements.
- Through experiments with a luciferase reporter linked to the chicken GH gene, researchers identified a specific GC-responsive region that includes binding sites for the protein ETS-1 and a degenerate GRE (dGRE), crucial for the hormone's induction.
- The study found that ETS-1 and the glucocorticoid receptor (GR) are essential for binding to this regulatory region, indicating a unique mechanism for GC modulation of GH gene expression during embryonic development, which is also relevant across different vertebrates.