Publications by authors named "Kristina Grunnet-Lauridsen"
Article Synopsis
- Cardiomyocytes derived from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are essential for studying heart development and disease and for drug testing.
- The study compares the morphology and function of hESC-derived cardiomyocytes with those from human embryonic/fetal hearts, highlighting that hESC-derived cells resemble native cells in characteristics like contracting ability and primary cilia presence.
- Electrophysiological analysis reveals differences in action potentials between atrial and ventricular cardiomyocytes, with early repolarization noted in atrial cells, and indicates that K11.1 channels are functionally important even in the early stages of heart development.
The derivation of functional cardiomyocytes (CMs) from human embryonic stem cells (hESCs) represents a unique way of studying human cardiogenesis, including the development of CM subtypes. In this study, we investigated the development and organization of hESC-derived cardiomyocytes (hESC-CMs) and examined how the expression levels of CM subtypes correspond to human in vivo cardiogenesis. Beating clusters were used to determine cardiac differentiation, which was evaluated by the expression of cardiac genes GATA4 and TNNT2 and subcellular localization of GATA4 and NKX2.
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