Publications by authors named "Kristina Durechova"
Recent evidence suggests that complex karyotype (CK) defined by the presence of ≥3 chromosomal aberrations (structural and/or numerical) identified by using chromosome-banding analysis (CBA) may be relevant for treatment decision-making in chronic lymphocytic leukemia (CLL). However, many challenges toward the routine clinical application of CBA remain. In a retrospective study of 5290 patients with available CBA data, we explored both clinicobiological associations and the clinical impact of CK in CLL.
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- Activation-induced cytidine deaminase (AID) is a crucial enzyme involved in immune processes, and its abnormal activity is linked to various cancers, including chronic lymphocytic leukemia (CLL).
- In a study of 149 CLL patients, researchers quantified different AID variants and found a connection between higher AID levels and trisomy of chromosome 12, a genetic abnormality.
- Functional assessments showed that the altered AID splice variants had reduced activity for important processes like somatic hypermutation and DNA break induction, and modeling studies suggested structural changes leading to their loss of function.