Publications by authors named "Kristina Campton"
Article Synopsis
- Hidradenitis suppurativa (HS) is an inflammatory skin condition linked to androgen levels, while polycystic ovary syndrome (PCOS) also involves high androgens, with past studies showing a connection between the two conditions.
- This study examined the relationship between HS and PCOS, considering socioeconomic status (SES) as a potential influencing factor that previous studies overlooked.
- Analysis of data from the All of Us database revealed that female HS patients had significantly higher rates of PCOS (8.8% vs. 4.3% in controls), with HS patients having a 1.34 to 2.17 times greater chance of having PCOS, even after adjusting for other medical conditions and SES
Dissecting cellulitis of the scalp (DCS) is a rare condition characterized by painful inflammatory nodules and abscesses on the scalp, often leading to sinus tracts and scarring alopecia. We present a case of DCS in a 26-year-old male who experienced significant clinical improvement following a short course of upadacitinib, a Janus kinase (JAK) inhibitor. The patient received multiple standard treatments such as topical antimicrobials, oral antibiotics, corticosteroids, and intralesional triamcinolone injections, with limited success.
View Article and Find Full Text PDFImportance: Hidradenitis suppurativa (HS) is a debilitating follicular skin disorder in which bacterial colonization is typical. Oral antibiotic efficacy can be unreliable; however, selective intravenous antibiotics, specifically ertapenem, may provide favorable clinical outcomes.
Objective: To explore optimal course duration, efficacy, and patient satisfaction associated with intravenous ertapenem for HS.
Article Synopsis
- * Research shows that patients with intellectual and developmental disabilities (IDD) experience HS more frequently and at a younger age compared to those without IDD.
- * A study at Albert Einstein College of Medicine-Montefiore HS Center analyzed 22 HS patients with IDD, revealing that diverse treatments such as antibiotics, hormonal therapies, and surgery are critical for managing the condition effectively.
Article Synopsis
- Efficacy of Adalimumab
- : A study of 57 hidradenitis suppurativa patients shows that adalimumab is significantly more effective in patients with a BMI under 30, leading to notable improvements in disease severity and inflammation markers.
- Impact of Obesity
- : Patients with a BMI of 30 or higher displayed increases in disease severity and inflammatory markers after treatment, indicating that obesity negatively affects the treatment's effectiveness.
- Need for Further Research
- : The findings suggest a need for more studies to explore how weight affects biologic treatment outcomes for hidradenitis suppurativa, emphasizing the importance of considering BMI in future treatment plans.
IL-10 is a pleiotropic cytokine that inhibits several immune parameters, including Th1 cell-mediated immune responses, antigen presentation, and antigen-specific T cell proliferation. Recent data implicate IL-10 as a mediator of suppression of cell-mediated immunity induced by exposure to UVB radiation (280-320 nm). To investigate the effects of IL-10 on the cutaneous immune system, we engineered transgenic mice that overexpress viral IL-10 (vIL-10) in the epidermis.
View Article and Find Full Text PDFThe sympathetic nervous system modulates immune function at a number of levels. Within the epidermis, APCs (Langerhans cells (LC)) are frequently anatomically associated with peripheral nerves. Furthermore, some neuropeptides have been shown to regulate LC Ag-presenting function.
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