Publications by authors named "Kristina Auf dem Brinke"
Background And Aims: Postinterventional hypothermia is a frequent complication in patients with large-vessel occlusion strokes (LVOS) after mechanical thrombectomy (MT). This inadvertent hypothermia might potentially have neuroprotective but also adverse effects on patients' outcomes. The aim of the study was to determine the rate of hypothermia in patients with LVOS receiving MT and its influence on functional outcome.
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- Chronic obstructive pulmonary disease (COPD) patients are at high risk for acute exacerbations and community-acquired pneumonia, highlighting the need for accurate differentiation between these conditions due to their differing treatments and outcomes.
- This study evaluated selected gene transcripts from peripheral blood mononuclear cells (PBMCs) to distinguish between patients with acute exacerbations of COPD, those with CAP and COPD, and CAP without prior COPD.
- The results indicated that specific gene expressions (YWHAG and others) effectively predicted disease conditions with up to 100% accuracy, significantly outperforming traditional clinical markers in differentiating AECOPD from CAP.
This investigation explores the potential of plasma lipidomic signatures for aiding in the diagnosis of Multiple Sclerosis (MS) and evaluating the clinical course and disease activity of diseased patients. Plasma samples from 60 patients with MS (PwMS) were clinically stratified to either a relapsing-remitting (RRMS) or a chronic progressive MS course and 60 age-matched controls were analyzed using state-of-the-art direct infusion quantitative shotgun lipidomics. To account for potential confounders, data were filtered for age and BMI correlations.
View Article and Find Full Text PDFBackground: Community-acquired pneumonia (CAP) and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) represent a major burden of disease and death and their differential diagnosis is critical. A potential source of relevant accessible biomarkers are blood-borne small extracellular vesicles (sEVs).
Methods: We performed an extracellular vesicle array to find proteins on plasma sEVs that are differentially expressed and possibly allow the differential diagnosis between CAP and AECOPD.