Publications by authors named "Kristina Andrijkova"
Article Synopsis
- The gut microbiota of pediatric oncology patients undergoing hematopoietic stem cell transplantation may influence the occurrence of febrile neutropenia, particularly through shifts in antibiotic-resistant pathogens.
- A study involving 18 patients revealed a significant drop in gut microbiome diversity and identified multiple antibiotic-resistance genes one week post-transplant, linked to febrile neutropenia.
- Key findings indicated that over 50% of patients treated with certain antibiotics harbored resistance genes, making the gut microbiome's diversity and resistome potential indicators of febrile neutropenia outcomes.
Antibiotics (Basel)
November 2023
Article Synopsis
- Graft-versus-host disease (GvHD) is a dangerous complication that can occur after hematopoietic stem cell transplantation (HSCT), and this study focused on the connection between GvHD and multidrug-resistant (MDR) gut bacteria in pediatric patients.
- By analyzing 11 children with acute lymphoblastic leukemia before and after HSCT, the researchers found that GvHD patients had an increase in harmful MDR bacteria and a decline in gut microbiome diversity shortly after the procedure.
- The study suggests that certain beneficial MDR bacteria could help maintain gut diversity and boost the immune response, potentially reducing the risk of GvHD in these patients, indicating important therapeutic possibilities.
