Publications by authors named "Kristina A Betters"

Article Synopsis
  • A retrospective study in a pediatric intensive care unit assessed the impact of a risk stratified sedation weaning protocol on medication costs and patient outcomes over a two-year period.
  • The results showed that implementing the protocol reduced total sedation weaning costs significantly from approximately $400,329 to around $170,459, with lower median costs per patient.
  • Despite the cost reduction, the incidence of withdrawal symptoms before and after the protocol remained similar, indicating that patient outcomes were not adversely affected by the change.
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Objective: ICU delirium commonly complicates critical illness associated with factors such as cardiopulmonary bypass (CPB) time and the requirement of mechanical ventilation (MV). Recent reports associate hyperoxia with poorer outcomes in critically ill children. This study sought to determine whether hyperoxia on CPB in pediatric patients was associated with a higher prevalence of postoperative delirium.

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Article Synopsis
  • Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants in the U.S., prompting the CDC to recommend nirsevimab, a monoclonal antibody, for infants under 8 months and at-risk children aged 8-19 months to prevent severe infection during their first RSV season.
  • In clinical trials, nirsevimab showed an 81% efficacy rate for preventing RSV-related hospitalizations, while a recent analysis during RSV season (October 2023-February 2024) reported a 90% effectiveness among treated infants.
  • Despite limited numbers of treated infants, the findings support ongoing recommendations for nirsevimab and emphasize the importance of maternal vaccination or direct nirsevimab administration
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Article Synopsis
  • This study investigated the effects of ketamine on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in children with severe traumatic brain injury (TBI).
  • Using a retrospective analysis of 33 patients, the study found no increase in ICP after ketamine administration, which is significant as it suggests safety in using ketamine for sedation or during ICP crises.
  • Ketamine was associated with a decrease in ICP and an increase in CPP during ICP crises, indicating its potential as a therapeutic option for managing TBI in children if confirmed in further research.
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Introduction: Delirium is a disturbance of attention and awareness that represents a change from baseline mental status. Accurate diagnosis of delirium is of paramount importance to improving the management of pediatric delirium in the intensive care unit. Despite ongoing education, inconsistencies in delirium assessments occur.

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Purpose: Early mobility (EM) and patient communication have known benefits for critically ill patients, but perceived barriers exist, notably related to family and caregiver concerns. Caregiver perceptions of an EM and communication therapy protocol in the pediatric intensive care unit (PICU) were assessed.

Methods: Caregivers of PICU patients at a free-standing academic children's hospital completed a survey using a Likert-type agreement scale on their perceptions surrounding the safety of EM, benefits of EM and communication, and barriers to EM and communication services.

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Rationale: A guideline that both evaluates current practice and provides recommendations to address sedation, pain, and delirium management with regard for neuromuscular blockade and withdrawal is not currently available.

Objective: To develop comprehensive clinical practice guidelines for critically ill infants and children, with specific attention to seven domains of care including pain, sedation/agitation, iatrogenic withdrawal, neuromuscular blockade, delirium, PICU environment, and early mobility.

Design: The Society of Critical Care Medicine Pediatric Pain, Agitation, Neuromuscular Blockade, and Delirium in critically ill pediatric patients with consideration of the PICU Environment and Early Mobility Guideline Taskforce was comprised of 29 national experts who collaborated from 2009 to 2021 via teleconference and/or e-mail at least monthly for planning, literature review, and guideline development, revision, and approval.

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Assessing functional motor changes and their relationship to discharge needs in the pediatric intensive care unit (PICU) population is difficult given challenges quantifying small functional gains with current tools. Therefore, we compared the Physical Abilities and Mobility Scale (PAMS) to the Functional Status Scale (FSS) in PICU patients to assess correlation and differences and association with discharge needs. This study was a retrospective chart review of all patients (2-18 years old) admitted to the PICU and cardiac PICU for over 9 months who received early mobility services, including PAMS and FSS scoring.

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Article Synopsis
  • ICU delirium, a serious condition, is common in babies under 6 months old and can lead to worse health outcomes.
  • A study tested a special method called the Preschool Confusion Assessment Method to see if it can effectively find delirium in these young infants.
  • The results showed that this method is a good way to check for delirium, with nearly half of the babies in the study showing signs of it.
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Objectives: To describe rehabilitation practice patterns among critically ill children with prolonged ICU stays and explore the association between institution-level utilization of rehabilitative services and patient outcomes.

Design: Retrospective cohort study using an administrative database of inpatient clinical and resource utilization data from participating pediatric hospitals in the United States. Center-level utilization of physical therapy and occupational therapy among critically ill patients was used to divide hospitals by quartile into high utilization centers or standard utilization centers.

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Background: Accurate anthropometric measurements are essential for assessing nutritional status, monitoring child growth, and informing clinical care. We aimed to improve height measurements of hospitalized pediatrics patients through implementation of gold standard measurement techniques.

Methods: A quality improvement project implemented computerized training modules on anthropometry and standardized wooden boards for height measurements in a tertiary children's hospital.

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Objectives: Early mobility in the PICU is safe and feasible. However, PICUs continue to meet barriers to implementing early mobility. PICU providers were surveyed before and after initiating an early mobility protocol to determine perceived barriers and continued challenges in performing early mobility.

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Purpose: Early mobility (EM) is being used in adult ICUs in an effort to treat and prevent intensive care unit acquired weakness (ICU-AW) and Post-Intensive Care Syndrome (PICS). Data supports children suffer from ICU-AW and PICS as well. Our objective was to create and implement an EM protocol for pediatric patients receiving invasive mechanical ventilation.

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Objective: High-flow nasal cannula use in the PICU continues to increase; however, a protocol for weaning patients has yet to be published. This study aimed to create an efficient and safe protocol for weaning high-flow nasal cannula.

Design: A Respiratory Assessment Score was created using two validated scoring systems.

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Objectives: High flow nasal cannula (HFNC) use is increasing in pediatrics. Few studies exist examining the safety of HFNC use outside the intensive care unit (ICU). This study aimed to characterize patient qualities associated with failure of HFNC use outside the ICU.

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