Publications by authors named "Kristin Sudol"
Objective: The objective of this article is to study the effect of PC-815, a novel combination microbicide containing carrageenan and the nonnucleoside reverse transcriptase inhibitor (NNRTI) MIV-150, in blocking HIV-1 and HIV-2 infections in vitro as compared with Carraguard alone.
Goal: The goal of this study was to develop a combination microbicide that is more efficacious than Carraguard against HIV-1 and HIV-2.
Study Design: The microtiter syncytial assay was used to evaluate: 1) the antiviral and virucidal activity of MIV-150 against HIV-1MN; 2) the additive effect of MIV-150 when combined with carrageenan; and 3) a possible interference of seminal fluid in the antiviral activity of these compounds.
It has been shown that men who have sex with men actively seek lubricants that contain nonoxynol-9 (N-9) because they believe that N-9 may help to prevent infection by HIV. However, indirect evidence suggests that N-9 may actually enhance infection. Microscopic examination of rectal lavage and biopsy specimens collected at different time points following rectal application of a lubricant containing 2% N-9 showed rapid exfoliation of the rectal epithelium.
View Article and Find Full Text PDFObjectives: To develop an accurate, rapid, and inexpensive method for verifying vaginal applicator use.
Goal: To develop a method for assessing compliance in microbicide clinical trials.
Study Design: Single use Microlax applicators containing a placebo formulation either were or were not exposed to the vagina.
Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use.
Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium.
Study Design: We describe a mouse assay to determine the degree to which lubricants cause rectal sloughing.