Publications by authors named "Kristin Stieglmaier"
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Synopsis of recent research by authors named "Kristin Stieglmaier"
- Kristin Stieglmaier's research primarily focuses on the development and optimization of antibody therapeutics, particularly chimeric and bispecific antibodies, for the treatment of hematological malignancies such as leukemias and lymphomas.
- One notable study investigated the impact of variable N-glycosylation on the cytolytic efficacy of chimeric CD19 antibodies, revealing significant differences in antibody functionality based on expression systems used for production.
- Another key finding highlighted the successful design of a stabilised bispecific single-chain antibody targeting CD19 and CD16, which aims to enhance targeted lysis of lymphoma cells while minimizing undesired immune responses associated with whole antibodies.
