Introduction: Black pepper () is a rich source of natural and bioactive components such as N-trans-feruloyltyramine (NFT). In this paper, we discuss the results of the subchronic toxicity and mutagenicity studies conducted to understand the potential for adverse effects if any, of Black Pepper Extract Preparation (BPE).
Methods: To evaluate mutagenicity, an Ames test was conducted with BPE in the presence and absence of S9 metabolic activation.