Publications by authors named "Kristin Morder"
Article Synopsis
- Traditional belief held that bloodstream infections (BSIs) were primarily caused by a single organism, but this study reveals mixed populations of genetically diverse strains of Candida glabrata in patients.
- Whole genome sequencing showed distinct genetic differences among these strains, impacting their susceptibility to antifungal treatments and their ability to evade the immune system.
- Findings indicate that the persistence and relapse of infections may be linked to a diversity of drug-resistant strains, highlighting the need for a population-based understanding of C. glabrata during BSIs.
Article Synopsis
- * Whole genome sequencing of strains from blood cultures of ten patients revealed that these mixed populations can have significant differences in their susceptibility to antifungal treatments.
- * The study indicates that this genetic diversity can lead to the recovery of both susceptible and resistant strains during infections, suggesting a need for a new understanding of how these infections behave and progress.
Introduction: We previously showed that caspase-1 and -11, which are activated by inflammasomes, mediate recovery from muscle ischemia in mice. We hypothesized that similar to murine models, inflammatory caspases modulate myogenicity and inflammation in ischemic muscle disease. Methods: Caspase activity was measured in ischemic and perfused human myoblasts in response to the NLRP3 and AIM2 inflammasome agonists (nigericin and poly(dA:dT), respectively) with and without specific caspase-1 or pan-caspase inhibition.
View Article and Find Full Text PDFWhile neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs can directly interact with infiltrating T cells to promote an immunosuppressive TME. Herein, to induce a NET-rich TME, we performed liver Ischemia/Reperfusion (I/R) in an established cancer metastasis model or directly injected NETs in subcutaneous tumors.
View Article and Find Full Text PDFBackground And Aims: Liver ischemia/reperfusion injury (IRI) induces local and systemic inflammation in which neutrophil extracellular traps (NETs) are major drivers. IRI markedly augments metastatic growth, which is consistent with the notion that the liver IRI can serve as a premetastatic niche. Exercise training (ExT) confers a sustainable protection, reducing IRI in some animal models, and has been associated with improved survival in patients with cancer; however, the impact of ExT on liver IRI or development of hepatic metastases is unknown.
View Article and Find Full Text PDFMeropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant (CRE) infections. We describe the activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered isolates harboring mutant genes associated with ceftazidime-avibactam resistance. We also compared disk diffusion and gradient strip testing methods to standard broth microdilution methods.
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