Publications by authors named "Kristin Lyman"

Background: SARS-CoV-2-infected patients may develop new conditions in the period after the acute infection. These conditions, the post-acute sequelae of SARS-CoV-2 infection (PASC, or Long COVID), involve a diverse set of organ systems. Limited studies have investigated the predictability of Long COVID development and its associated risk factors.

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Article Synopsis
  • The study investigates how the characteristics and frequency of post-acute sequelae of SARS-CoV-2 infection (PASC) differ between those infected by the ancestral strain in 2020 and the Delta variant in 2021.
  • It analyzes a significant dataset of around 27 million patients across New York and Florida to assess new health conditions arising 31-180 days post COVID-19 infection.
  • Key findings reveal that during the ancestral strain period, issues like pulmonary fibrosis and dyspnea were prominent, while the Delta variant was mainly associated with an increased risk of pulmonary embolism.
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Recent studies have investigated post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) using real-world patient data such as electronic health records (EHR). Prior studies have typically been conducted on patient cohorts with specific patient populations which makes their generalizability unclear. This study aims to characterize PASC using the EHR data warehouses from two large Patient-Centered Clinical Research Networks (PCORnet), INSIGHT and OneFlorida+, which include 11 million patients in New York City (NYC) area and 16.

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Background: Patients who were SARS-CoV-2 infected could suffer from newly incidental conditions in their post-acute infection period. These conditions, denoted as the post-acute sequelae of SARS-CoV-2 infection (PASC), are highly heterogeneous and involve a diverse set of organ systems. Limited studies have investigated the predictability of these conditions and their associated risk factors.

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Importance: The frequency and characteristics of post-acute sequelae of SARS-CoV-2 infection (PASC) may vary by SARS-CoV-2 variant.

Objective: To characterize PASC-related conditions among individuals likely infected by the ancestral strain in 2020 and individuals likely infected by the Delta variant in 2021.

Design: Retrospective cohort study of electronic medical record data for approximately 27 million patients from March 1, 2020-November 30, 2021.

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Article Synopsis
  • The study investigates post-acute sequelae of SARS-CoV-2 (PASC), which are long-lasting symptoms that occur after the initial infection.
  • Using health records from two large patient cohorts, the researchers identified four main PASC subphenotypes related to cardiac, respiratory, musculoskeletal, and digestive issues.
  • The findings highlight the diversity in PASC experiences among patients, suggesting that understanding these different subphenotypes can help improve patient management and treatment approaches.
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Background: It is increasingly recognized that policies have played a role in both alleviating and exacerbating the health and economic consequences of the COVID-19 pandemic. There has been limited systematic evaluation of variation in U.S.

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Article Synopsis
  • The post-acute sequelae of SARS-CoV-2 infection (PASC) includes a range of ongoing or new symptoms that occur after the initial COVID-19 infection period.
  • Researchers utilized electronic health records to analyze newly diagnosed conditions in patients 30 to 180 days post-infection.
  • The study identified four distinct subphenotypes of PASC related to different body systems, revealing patterns related to patient demographics, prior health conditions, infection severity, and medication use in recovery.
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Purpose: Unprecedented efforts are underway across the United States to electronically capture and exchange health information to improve health care and population health, and reduce costs. This increased collection and sharing of electronic patient data raises several governance issues, including privacy, security, liability, and market competition. Those engaged in such efforts have had to develop data sharing agreements (DSAs) among entities involved in information exchange, many of whom are "nontraditional" health care entities and/or new partners.

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