Cytochrome P450 2C19 Poor Metabolizer Phenotype in Treatment Resistant Depression: Treatment and Diagnostic Implications.

Pharmacogenomic testing, specifically for pharmacokinetic (PK) and pharmacodynamic (PD) genetic variation, may contribute to a better understanding of baseline genetic differences in patients seeking treatment for depression, which may further impact clinical antidepressant treatment recommendations. This study evaluated PK and PD genetic variation and the clinical use of such testing in treatment seeking patients with bipolar disorder (BP) and major depressive disorder (MDD) and history of multiple drug failures/treatment resistance. Consecutive depressed patients evaluated at the Mayo Clinic Depression Center over a 10-year study time frame (2003-2013) were included in this retrospective analysis.

Use of a Gabapentin Protocol for the Management of Alcohol Withdrawal: A Preliminary Experience Expanding From the Consultation-Liaison Psychiatry Service.

Background: Benzodiazepines are the conventional mainstay to manage alcohol withdrawal; however, patients are subsequently at increased risk for poor sleep, cravings, and return to drinking. Research on alternative pharmacologic agents to facilitate safe alcohol withdrawal is scant. Gabapentin is one medication shown in small studies to reduce the need for benzodiazepines in the setting of alcohol withdrawal.

Mirtazapine for Symptomatic Relief on a Psychiatric Consultation Service: A Case Series.

Background: With a complex pharmacologic profile, mirtazapine may promote sleep, stimulate appetite, improve nausea, and reduce pain. Some practitioners working on the Mayo Clinic inpatient psychiatric consultation/liaison service have recommended mirtazapine in medically ill patients with or without formal psychiatric comorbidity to target these symptoms.

Objective: To assess the success of this practice, we conducted a retrospective chart review covering a 4.

Temporal dynamics of the action-sentence compatibility effect.

A number of recent studies have demonstrated variants of the action-sentence compatibility effect (ACE), wherein the execution of a motor response is facilitated by the comprehension of sentences that describe actions taking place in the same direction as the motor response (e.g., a sentence about action towards one's body facilitates the execution of an arm movement towards the body).

Is long-term structural priming affected by patterns of experience with individual verbs?

Several recent papers have reported long-term structural priming effects in experiments where previous patterns of experience with the double object and prepositional object constructions are shown to affect later patterns of language production for those constructions. The experiments reported in this paper address the extent to which these long-term priming effects are modulated by the participants' patterns of experience with particular verbs within the double object and prepositional object constructions. The results of three experiments show that patterns of experience with particular verbs using the double object or prepositional object constructions do not have much effect on the shape of the longterm structural priming effects reported elsewhere in the literature.

The Action-Sentence Compatibility Effect: It's All in the Timing.

When participants are asked to make sensibility judgments on sentences that describe action toward the body (i.e., "Mark dealt the cards to you") or away from the body (i.

Recent experience affects the strength of structural priming.

In two experiments, we explore how recent experience with particular syntactic constructions affects the strength of the structural priming observed for those constructions. The results suggest that (1) the strength of structural priming observed for double object and prepositional object constructions is affected by the relative frequency with which each construction was produced earlier in the experiment, and (2) the effects of relative frequency are not modulated by the temporal placement of the tokens of each construction within the experiment.