Accelerated Unilateral Radiographic Huntingtonian Changes Following Neoadjuvant Chemotherapy for a Nongerminomatous Germ Cell Tumor Leading to Identification of Occult Disease in the Dorsal Striatum.

Basal ganglia nongerminomatous germ cell tumors comprise 10% to 15% of germ cell tumor and have substantial morbidity at the time of local failure. In this submitted image we present a case where neoadjuvant chemotherapy unmasked a unilateral caudate head loss consistent with Huntingtonian changes. Careful review of the patient's imaging identified disease within the dorsal striatum that was not previously identified at the time of diagnosis.

Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases.

Background: To determine the clinical benefits of systemic targeted agents across multiple histologies after stereotactic radiosurgery (SRS) for brain metastases.

Methods: Between 2000 and 2013, 737 patients underwent upfront SRS for brain metastases. Patients were stratified by whether or not they received targeted agents with SRS.

Management of nerve sheath tumors arising in the sympathetic chain.

Background: Extradural schwannomas arising from the sympathetic chain are uncommon benign nerve sheath tumors. We present our experience with three patients having such tumors located in the cervical, thoracic and lumbar regions and we describe clinical presentation, surgical treatment, and outcomes.

Methods: Between 2002 and 2006, the medical records of three patients with pathologically proven sympathetic schwannomas at the Moffitt Cancer Center were reviewed retrospectively.