Predicting severe COVID-19 in the Emergency Department.

Background: COVID-19 may lead to severe disease, requiring intensive care treatment and challenging the capacity of health care systems. The aim of this study was to compare the ability of commonly used scoring systems for sepsis and pneumonia to predict severe COVID-19 in the emergency department.

Methods: Prospective, observational, single centre study in a secondary/tertiary care hospital in Oslo, Norway.

Elevated Levels of Anti-Inflammatory Eicosanoids and Monocyte Heterogeneity in Infection and Disease.

Eicosanoids modulate both innate and adaptive immune responses in infection and have been suggested as possible Host Directed Therapy (HDT) targets, but more knowledge of eicosanoid dynamics in infection is required. We investigated the levels and ratios of eicosanoid mediators and their cellular sources, monocyte subsets and CD4 T cells in Tuberculosis (TB) patients with various clinical states of infection. Patients consenting to prospective enrolment in a TB quality registry and biorepository, 16 with pulmonary TB (before and at-end-of treatment), 14 with extrapulmonary TB and 17 latently infected (LTBI) were included.