Why doesn't the brain lose weight, when obese people diet?

Objective: As has been shown recently, obesity is associated with brain volume deficits. We here used an interventional study design to investigate whether the brain shrinks after caloric restriction in obesity. To elucidate mechanisms of neuroprotection we assessed brain-pull competence, i.

Impact of intra- and extra-osseous soft tissue composition on changes in bone mineral density with weight loss and regain.

Recent studies report a significant gain in bone mineral density (BMD) after diet-induced weight loss. This might be explained by a measurement artefact. We therefore investigated the impact of intra- and extra-osseous soft tissue composition on bone measurements by dual X-ray absorptiometry (DXA) in a longitudinal study of diet-induced weight loss and regain in 55 women and 17 men (19-46 years, BMI 28.

Measurement site for waist circumference affects its accuracy as an index of visceral and abdominal subcutaneous fat in a Caucasian population.

Following experts' consensus, waist circumference (WC) is the best anthropometric obesity index. However, different anatomic sites are used, and currently there is no universally accepted protocol for measurement of WC. In this study, we compare the associations between WC measured at different sites with total visceral adipose tissue (VAT) volume and cardiometabolic risk.

Association of pericardial fat with liver fat and insulin sensitivity after diet-induced weight loss in overweight women.

Pericardial adipose tissue (PAT) is positively associated with fatty liver and obesity-related insulin resistance. Because PAT is a well-known marker of visceral adiposity, we investigated the impact of weight loss on PAT and its relationship with liver fat and insulin sensitivity independently of body fat distribution. Thirty overweight nondiabetic women (BMI 28.

Influence of changes in body composition and adaptive thermogenesis on the difference between measured and predicted weight loss in obese women.

Background: There is a difference between measured and predicted weight loss in obese patients. This might be explained by the composition of weight loss, adaptive thermogenesis, or poor compliance.

Patients And Methods: 48 overweight and obese female patients (31.

Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure.

Background: Weight loss leads to reduced resting energy expenditure (REE) independent of fat-free mass (FFM) and fat mass (FM) loss, but the effect of changes in FFM composition is unclear.

Objective: We hypothesized that a decrease in REE adjusted for FFM with weight loss would be partly explained by a disproportionate loss in the high metabolic activity component of FFM.

Design: Forty-five overweight and obese women [body mass index (in kg/m(2)): 28.