Publications by authors named "Kristin Fredrich"
Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by performing microinjections at the living lamprey giant reticulospinal synapse.
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- Neurotransmission relies on synaptic vesicles (SVs) releasing neurotransmitters at the synapse, with a need for replenishment from a reserve pool during high activity.
- Synapsins play a key role in maintaining this reserve pool and regulating the mobilization of SVs, but how this process works with other factors is not fully understood.
- The study identifies intersectin, a scaffold protein, as crucial for SV replenishment, demonstrating that its interaction with synapsin I is essential for sustaining neurotransmission, highlighting its role in linking reserve pools to the endocytosis machinery at synapses.