Publications by authors named "Kristin Ewing"
Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut microbiota, in facilitating weight loss and resolving associated comorbidities.
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- * Results showed that after vertical sleeve gastrectomy, serum bile acid levels significantly increased, while the Roux-en-Y gastric bypass showed a trend toward increased bile acids, and caloric restriction led to a decrease in one type of bile acid.
- * Despite the increases in serum bile acids post-surgery, the expression of TGR5 in white adipose tissue decreased, suggesting that bariatric surgery affects bile acids independently of caloric restriction, but TGR5 protein levels remain unchanged.