Publications by authors named "Kristin Coffan"
Background: Patients with T-cell acute lymphoblastic leukemia and lymphoma (T-ALL/LLy) commonly present with critical features such as hyperleukocytosis and mediastinal mass, which complicates completing a diagnostic and staging workup and prevents clinical trial enrollment.
Procedure: Consecutive patients with T-ALL/LLy from 1999 to 2019 at the Children's Hospital of Philadelphia were analyzed for pediatric intensive care unit (PICU) admission and various high-risk features as well as clinical trial enrollment and outcome.
Results: We identified 153 patients newly diagnosed with T-ALL/LLy, 53 (35%) required PICU-level care within 24 hours and 73 (48%) within 7 days.
Article Synopsis
- Adolescents and young adults (AYAs) with acute lymphoblastic leukemia see better outcomes with pediatric-inspired treatment, as shown in the CALGB 10403 study, which assessed this approach in patients up to 40 years old.
- The study found that the toxicity rates were generally similar to those observed in a related Children's Oncology Group study (COG AALL0232), although some serious adverse events were more frequent in CALGB 10403.
- Despite a low mortality rate of 4% in CALGB 10403, only 39% of patients completed the full treatment, indicating potential challenges related to age and treatment adherence that could be improved with more experience with the regimen.