Publications by authors named "Kristin A Kirkby"

Article Synopsis
  • The study aimed to collect algometric readings to understand how various factors might affect pain sensitivity in normal dogs.
  • Nineteen skeletally mature dogs of different sexes and neuter statuses were subjected to pressure testing at twelve surgical sites to measure their pain response.
  • Results showed that factors such as the individual dog, testing order, site, time of day, and repetition influenced the readings, indicating that dogs learned to anticipate the pressure stimulus, resulting in lower pain threshold responses over time.
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Background And Objective: To investigate the effects of low-level laser therapy applied to the serosal surface of the rat jejunum following ischemia and reperfusion.

Materials And Methods: Ninety-six male Sprague-Dawley rats were assigned to 15 groups and anesthetized. Small intestinal ischemia was induced by clamping the superior mesenteric artery for 60 minutes.

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Objective: To systematically review the evidence available for nonsurgical management of hip dysplasia (HD).

Study Design: Literature review.

Methods: Databases (Pubmed, Veterinary Information Network) were searched for clinical studies on nonsurgical management of HD in dogs.

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Case Description: A 4-year-old spayed female Boxer was evaluated for a cutaneous mass located on the dorsum. The mass had been present for 6 weeks and was increasing in size.

Clinical Findings: A mass of approximately 10 cm in diameter was detected on the dorsum cranial to the right ilial wing.

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Vacuum-assisted closure (VAC) is a wound management system that exposes a wound bed to local negative pressure to promote healing. Benefits of VAC therapy include removal of fluid from the extravascular space, improved circulation, enhanced granulation tissue formation, and increased bacterial clearance. VAC therapy has been used extensively in human patients to treat a variety of acute and chronic wound conditions.

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The radiographic and clinical results from 17 dogs (18 limbs) in which hybrid linear-circular external fixators (HLCEF) were used for the correction of antebrachial growth deformities (AGD) are described, retrospectively. Wedge ostectomy and the application of a type IA or IB HLCEF were performed in all cases. Pre- and postoperative AGD measurements, complications, time to staged destabilization and/or fixator removal, cosmesis, and limb function were evaluated.

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Linear-circular hybrid fixators were used to stabilize humeral and femoral fractures in 21 dogs and five cats. Twenty-two of 24 fractures with sufficient follow-up radiographic evaluation obtained union. Time to radiographic union ranged from 25 to 280 days (mean +/- standard deviation [SD] 110+/-69 days; median 98 days).

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Heme oxygenase 1 (HO-1) is induced in response to cellular stress and is responsible for converting the prooxidant heme molecule into equimolar quantities of biliverdin (BV), carbon monoxide (CO), and iron. BV is then converted to bilirubin (BR) by the enzyme biliverdin reductase. Experimental evidence suggests that induction of the HO system is an important endogenous mechanism for cytoprotection and that the downstream products of heme degradation, CO, BR, and BV, may mediate these powerful beneficial effects.

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