Publications by authors named "Kristie A Jones"
Article Synopsis
- Multiple System Atrophy (MSA) is a deadly neurodegenerative disease linked to protein aggregation and shares similarities with Parkinson's disease; its complexity and fast progression make drug development challenging.
- Researchers have created a cohort of 69 carefully assessed MSA patients and are recruiting them into a unique clinical trial setup that tracks individual patient progress over time.
- The study includes extensive patient phenotyping, collection of biospecimens, and development of induced pluripotent stem cell (iPSC) models to enhance understanding of MSA and improve chances of successful therapies through personalized medicine.
Differentiating multiple system atrophy (MSA) from related neurodegenerative movement disorders (NMD) is challenging. MRI is widely available and automated decision-tree analysis is simple, transparent, and resistant to overfitting. Using a retrospective cohort of heterogeneous clinical MRIs broadly sourced from a tertiary hospital system, we aimed to develop readily translatable and fully automated volumetric diagnostic decision-trees to facilitate early and accurate differential diagnosis of NMDs.
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