[F]PSMA-1007 PET is comparable to [Tc]Tc-DMSA SPECT for renal cortical imaging.

Background: Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([Tc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [Tc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer.

Quantitative myocardial perfusion should be interpreted in the light of sex and comorbidities in patients with suspected chronic coronary syndrome: A cardiac positron emission tomography study.

Diagnosis and treatment of patients with suspected chronic coronary syndrome (CCS) currently relies on the degree of coronary artery stenosis and its significance for myocardial perfusion. However, myocardial perfusion can be affected by factors other than coronary stenosis. The aim of this study was to investigate to what extent sex, age, diabetes, hypertension and smoking affect quantitative myocardial perfusion, beyond the degree of coronary artery stenosis, in patients with suspected or established CCS.

First clinical experience of a ring-configured cadmium zinc telluride camera: A comparative study versus conventional gamma camera systems.

Background: A novel semiconductor cadmium zinc telluride (CZT) gamma camera system using a block sequential regularized expectation maximization (BSREM) reconstruction algorithm is now clinically available. Here we investigate how a multi-purpose ring-configurated CZT system can be safely applied in clinics and describe the initial optimization process.

Method: Seventy-six patients (bone-, cardiac- and lung scan) were scanned on a conventional gamma camera (planar and/or single-photon emission computed tomography [SPECT]/SPECT-CT) used in clinical routine and on the ring-configurated CZT camera Starguide (GE Healthcare).

AI-based quantification of whole-body tumour burden on somatostatin receptor PET/CT.

Background: Segmenting the whole-body somatostatin receptor-expressing tumour volume (SRETVwb) on positron emission tomography/computed tomography (PET/CT) images is highly time-consuming but has shown value as an independent prognostic factor for survival. An automatic method to measure SRETVwb could improve disease status assessment and provide a tool for prognostication. This study aimed to develop an artificial intelligence (AI)-based method to detect and quantify SRETVwb and total lesion somatostatin receptor expression (TLSREwb) from [Ga]Ga-DOTA-TOC/TATE PET/CT images.

[ F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate.

Background: Scintigraphy with technetium-99m-labelled dimercaptosuccinic acid ([ Tc]Tc-DMSA) is widely used for renal cortical imaging. Uptake of [ Tc]Tc-DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging.

Freely Available, Fully Automated AI-Based Analysis of Primary Tumour and Metastases of Prostate Cancer in Whole-Body [F]-PSMA-1007 PET-CT.

Here, we aimed to develop and validate a fully automated artificial intelligence (AI)-based method for the detection and quantification of suspected prostate tumour/local recurrence, lymph node metastases, and bone metastases from [F]PSMA-1007 positron emission tomography-computed tomography (PET-CT) images. Images from 660 patients were included. Segmentations by one expert reader were ground truth.

Dose-reduced [F]PSMA-1007 PET is feasible for functional imaging of the renal cortex.

Background: In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [F]PSMA-1007 has not been explored.

Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke.

Activation of the sigma-1 receptor (Sig-1R) improves functional recovery in models of experimental stroke and is known to modulate microglia function. The present study was conducted to investigate if Sig-1R activation after experimental stroke affects mediators of the inflammatory response in the ischemic hemisphere. Male Wistar rats were subjected to transient occlusion of the middle cerebral artery (MCAO) and injected with the specific Sig-1R agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) or saline for 5 days starting on day 2 after MCAO.