Publications by authors named "Kristian Koch"
BMC Pharmacol
December 2009
Article Synopsis
- The study investigates how muscarinic M1 receptors react to two types of agonists: orthosteric (like carbachol and pilocarpine) and allosteric (like AC-42 and xanomeline).
- Both types of agonists activated the receptors and caused a reduction in receptor binding at the cell surface, but only orthosteric agonists allowed internalized receptors to recycle back to the surface after removal.
- The findings suggest that allosteric agonists have a unique regulatory influence on M1 receptors compared to orthosteric agonists, indicating that different ligands induce specific signaling and regulatory pathways.
