Publications by authors named "Kristian Kleine Schaars"
Article Synopsis
- Variability in cytochrome P450 enzymes (CYP2C19 and CYP2D6) may affect the side effects and effectiveness of commonly used antipsychotics like aripiprazole and risperidone, which are primarily metabolized by CYP2D6.
- A systematic review analyzed 2007 publications, ultimately including 34 studies, and evaluated their quality using specific assessment tools, revealing concerns such as high risk of bias in most randomized controlled trials (RCTs).
- The majority of studies focused on CYP2D6 without strong evidence linking it to side effects, while only one study found a positive relation of CYP2C19 with neurological side effects from risperidone; thus, more
Due to the chronic relapsing nature of mental disorders and increased life expectancy, the societal burden of these non-communicable diseases will increase even further. Treatments for mental disorders, such as depression, are available, but their effect is limited due to patients' (genetic) heterogeneity, low treatment compliance and frequent side effects. In general, only one-third of the patients respond to treatment.
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