Publications by authors named "Kristian K Pedersen"

Article Synopsis
  • A study using RNA sequencing showed that BCC induction in murine skin resulted in significant gene upregulation, with treatments like AFL and the hedgehog inhibitor vismodegib reversing these changes, though vismodegib was more effective.
  • Both treatments increased immune cell infiltration in the skin, with AFL notably recruiting a larger number of immune cells, suggesting different mechanisms at play that could inform future combined treatment strategies.
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Background: Systemically delivered hedgehog inhibitors including vismodegib and sonidegib are widely used to treat basal cell carcinomas (BCCs). Ablative fractional laser (AFL)-assisted topical delivery of vismodegib has been demonstrated in preclinical studies. The aim of this explorative clinical study was to evaluate intratumoral vismodegib concentrations and effect on hedgehog pathway gene expression following AFL-assisted topical vismodegib delivery to BCCs.

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This study aimed to investigate the impact of ablative fractional laser (AFL) on hedgehog pathway gene expression in murine microscopic basal cell carcinomas (BCCs) and compare these results to the effect of topical treatment with vismodegib, an FDA-approved hedgehog inhibitor. In 25 mice, 1 cm skin test sites (n = 44) containing microscopic BCCs were exposed to one of three interventions: a single CO AFL treatment (1 pulse, 40 mJ/microbeam, wavelength 10.6 μm, 5% density, pulse rate 250 Hz, n = 12), eight topical vismodegib treatments (3.

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Systemic treatment with hedgehog inhibitors (HHis) is available to treat basal cell carcinomas but their utility is limited by adverse effects. Topical delivery methods may reduce adverse effects, but successful topical treatment depends on sufficient skin uptake, biological response, and time in tumor tissue. The aim of this review was to evaluate the current status of topical HHi delivery for BCCs and discuss barriers for translating systemic HHis into topical treatments.

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B1 cells constitute a specialized subset of B cells, best characterized in mice, which is abundant in body cavities, including the peritoneal cavity. Through natural and antigen-induced antibody production, B1 cells participate in the early defense against bacteria. The G protein-coupled receptor 183 (GPR183), also known as Epstein-Barr virus-induced gene 2 (EBI2), is an oxysterol-activated chemotactic receptor that regulates migration of B cells.

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The involvement of a gut-bone axis in controlling bone physiology has been long suspected, although the exact mechanisms are unclear. We explored whether glucose-dependent insulinotropic polypeptide (GIP)-producing enteroendocrine K cells were involved in this process. The bone phenotype of transgenic mouse models lacking GIP secretion (GIP-GFP-KI) or enteroendocrine K cells (GIP-DT) was investigated.

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Synopsis of recent research by authors named "Kristian K Pedersen"

  • - Kristian K Pedersen's recent research focuses on the therapeutic applications of ablative fractional laser (AFL) and hedgehog inhibitors for treating basal cell carcinomas (BCCs), particularly examining their effects on gene expression and immune response in murine models.
  • - His studies demonstrate that AFL treatment significantly alters the transcriptomic landscape of early-stage BCCs by inducing gene upregulation, highlighting its potential to enhance localized cancer treatment strategies.
  • - Additionally, Pedersen explores the efficacy of laser-assisted topical delivery of vismodegib, indicating this method could effectively reduce hedgehog gene expression in human BCCs, thereby offering insights into more effective and less systemic treatment options for patients.

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