Publications by authors named "Kristian Chow"
Background/objectives: Risk prediction models (RPMs) for colorectal cancer (CRC) could facilitate risk-based screening. Models incorporating biomarkers may improve the utility of current RPMs. We performed a systematic review of studies reporting RPMs for CRC that evaluated the impact of blood-based biomarkers on clinical outcome prediction at the time of screening colonoscopy in average-risk populations.
View Article and Find Full Text PDFEarly-onset diagnosis, defined by age <40 years, has historically been associated with inferior outcomes in breast cancer. Recent evidence suggests that this association is modified by molecular subtype. We performed a systematic review and meta-analysis of the literature to synthesize evidence on the association between early-onset diagnosis and clinical outcomes in triple-negative breast cancer (TNBC).
View Article and Find Full Text PDFArticle Synopsis
- Increased demand for colonoscopy and rising colorectal cancer (CRC) rates in younger populations highlight the need to evaluate the performance of Fecal Immunochemical Tests (FIT) for CRC detection in individuals under 50.
- A systematic review identified three studies focusing on the sensitivity (19%-36%) and specificity (94%-97%) of FIT for detecting advanced neoplasia and CRC in this age group.
- Findings suggest that FIT may be less effective for younger individuals compared to older populations, indicating a need for further research to determine its adequacy as a screening tool in younger age groups.
Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis.
Clin Gastroenterol Hepatol
June 2022
Background & Aims: Despite the widespread increase in the incidence of early-onset colorectal cancer (EoCRC), the reasons for this increase remain unclear. The objective of this study was to determine risk factors for the development of EoCRC.
Methods: We conducted a systematic literature review and meta-analysis of studies examining non-genetic risk factors for EoCRC, including demographic factors, comorbidities, and lifestyle factors.