Publications by authors named "Kristi M Anderson"
Article Synopsis
- Vasoactive intestinal peptide (VIP) affects biological processes through two receptors, VIPR1 and VIPR2, but its clinical use is hindered by rapid metabolism and non-selectivity, potentially causing side effects.
- Researchers created stable, selective agonists for VIPR1 and VIPR2, demonstrating effectiveness in protecting against neurodegeneration in a Parkinson's disease mouse model.
- VIPR2 agonists not only preserved neuronal health but also reduced inflammation and shifted immune responses, indicating their potential as neuroprotective therapies for Parkinson’s disease.
Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. On the one hand immune responses can exacerbate neurotoxic responses; while on the other hand, they can lead to neuroprotective outcomes. The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.
View Article and Find Full Text PDFDNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals. DNA methylation contributes to the epigenetic control of gene transcription and is deregulated in virtually all human tumors. To better understand the generation of cancer-specific methylation patterns, we genetically inactivated Dnmt3b in a mouse model of MYC-induced lymphomagenesis.
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