Publications by authors named "Kristi L Bunde"
Toxicol Appl Pharmacol
September 2015
Article Synopsis
- FVB/N mice with varying expressions of Cyp 1b1 were studied for their response to different carcinogens in a two-stage skin tumor experiment, focusing on DBC, BaP, and CTE.
- The Cyp 1b1 null mice showed reduced tumor incidence and progression when initiated with DBC but not with BaP or CTE.
- Gene expression analysis indicated that the absence of Cyp 1b1 led to decreased levels of certain protective genes and a trend of reduced DNA adducts related to DBC, highlighting its critical role in DBC-induced skin carcinogenesis.
