Lyme Disease: A Potential Source for Culture-negative Prosthetic Joint Infection.

The presentation of Lyme arthritis can mimic periprosthetic joint infection (PJI) caused by typical bacterial organisms. A patient with left total knee arthroplasty (TKA) and chronic Lyme disease presented to our institution with Lyme-associated PJI. He complained of pain, erythema, and fever for 3 days and met Musculoskeletal Infection Society criteria for PJI.