Tissue-engineering the larynx: Effect of decellularization on human laryngeal framework and the cricoarytenoid joint.

Decellularization approaches have been commonly used as alternative techniques to reconstruct tissues. However, due to the complex tissue compartmentation of the larynx, the decellularization process may not retain the characteristics necessary for the successful recreation of the larynx. The aim of this study was to assess the effect of the decellularization process on the framework of the human cadaveric larynx generally and the cricoarytenoid joint specifically.

Analysis of palliative care treatment among head and neck patients with cancer: National perspective.

Background: To analyze the characteristics and survival patterns of patients with head and neck squamous cell carcinoma (SCC) who received palliative treatment during their first course of treatment.

Methods: Cohort analysis utilizing the National Cancer Data Base (NCDB) of patients with a diagnosis of oral cavity/oropharyngeal, hypopharyngeal, and laryngeal SCC. Statistical analysis included multivariate logistic regression and Cox Hazard ratio modeling, and Kaplan-Meier survival analysis.

Risk and survival of patients with medullary thyroid cancer: National perspective.

Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor account for 1-2% of thyroid cancer. In this study, we aim to examine the characteristics and survival of patients with MTC.

Methods: A retrospective cohort study utilizing the National Cancer Data Base, 2004-2014.

Otolaryngologic Emergencies in the Primary Care Setting.

Most otolaryngology-related complaints are straightforward and easily recognized and treated. However, given the proximity of the ears, nose, and throat to numerous vital structures in the head and neck, the potential for serious consequences exists if disease processes go unrecognized and untreated. This article serves to familiarize the primary care provider with the clinical presentation of various complications associated with common otolaryngologic complaints.

Reconstruction Outcomes Following Lateral Skull Base Resection.

Objective: Compare reconstruction outcomes for various lateral skull base closure techniques.

Study Design: Retrospective medical records review.

Setting: University-based tertiary referral center.

Ketorolac after free tissue transfer: a comparative effectiveness study.

Objective: We sought to compare postoperative pain and complications in patients undergoing free tissue transfer for reconstruction of head and neck defects with and without ketorolac.

Methods: In this retrospective cohort study, we identified patients who underwent head and neck free tissue transfer procedures at the University of Iowa between July 2010 and December 2012. A subset of patients received ketorolac as an anti-platelet agent.

Airway algorithm for the management of patients with a King LT.

Objectives/hypothesis: To discuss an algorithm for managing the airway in patients presenting with a King LT in place.

Study Design: Case series at a single institution with planned chart review.

Methods: This study reviewed the management of three patients who presented to a tertiary academic medical facility emergency department following placement of a King LT at an outside hospital or in the field.

Validation of a task-specific scoring system for a microvascular surgery simulation model.

Objective/hypothesis: Simulation models can help develop procedural skills outside the clinical setting while also providing a means for evaluation of trainees. Objective Structured Assessment of Technical Skills (OSATS) have been developed for several procedures. The purpose of this study was to demonstrate the construct validity of an OSATS for microvascular anastomosis performed on a simulation model using chicken thigh vessels.

Primary intraosseous cavernous hemangioma of the zygoma: a case report and literature review.

Intraosseous hemangiomas are rare. We report the case of a 47-year-old man who presented with a gradually enlarging left zygomatic mass that had caused pain, deformity, and superficial soft-tissue swelling. Computed tomography revealed a well-circumscribed 2.

Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension.

We present a calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base that was resected endoscopically. The clinical details are reported with a review of the relevant literature. CAPNON, although rare, should be considered in the differential diagnosis of tumors presenting along the anterior skull base with radiographic characteristics consistent with a fibro-osseous lesion.

Complex mandibular rehabilitation of a self-inflicted gunshot wound: a clinical report.

This report describes the surgical and prosthodontic rehabilitation of a patient traumatized by a self-inflicted gunshot wound to the mandible which required rehabilitation with a free fibula microvascular graft, single stage dental implant placement, and rehabilitation with CAD/CAM and laser assembled prosthetic components.

Use of the King LT for emergency airway management.

Objective: To discuss the role of the King LT reusable supraglottic airway in emergency airway management.

Design: Retrospective case series review.

Setting: Tertiary academic medical facility.

Adverse events associated with concurrent chemoradiation therapy in patients with head and neck cancer.

Objective: To assess toxicities, functional outcomes, and health-related quality of life associated with concurrent chemoradiation therapy (CRT) in patients with head and neck cancer.

Design: Prospective and retrospective outcomes study.

Setting: Tertiary care institution.

Pathology and FDG PET correlation of residual lymph nodes in head and neck cancer after radiation treatment.

Background: This study determines if postradiotherapy [18F]fluorodeoxyglucose positron emission tomography (FDG PET) can predict the pathology status of residual cervical lymph nodes in patients undergoing definitive radiotherapy for head and neck squamous cell carcinoma (HNSCC).

Methods: Patients with stage N2 or higher HNSCC underwent PET and CT imaging after definitive radiotherapy. Patients with radiographically persistent lymphadenopathy underwent either neck dissection or fine needle aspiration (FNA) of the lymph nodes under ultrasound guidance.

Is planned neck dissection necessary for head and neck cancer after intensity-modulated radiotherapy?

Purpose: The objective of this study was to determine regional control of local regional advanced head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiotherapy (IMRT), along with the role and selection criteria for neck dissection after IMRT.

Methods And Materials: A total of 90 patients with stage N2A or greater HNSCC were treated with definitive IMRT from December 1999 to July 2005. Three clinical target volumes were defined and were treated to 70 to 74 Gy, 60 Gy, and 54 Gy, respectively.

The failure patterns of oral cavity squamous cell carcinoma after intensity-modulated radiotherapy-the university of iowa experience.

Purpose: Determine the failure patterns of oral cavity squamous cell carcinoma (SCC) treated with intensity-modulated radiotherapy (IMRT).

Methods And Materials: Between May 2001 and July 2005, 55 patients with oral cavity SCC were treated with IMRT for curative intent. Forty-nine received postoperative IMRT, 5 definitive IMRT, and 1 neoadjuvant.

Scapula osteocutaneous free flap reconstruction of the head and neck: impact of flap choice on surgical and medical complications.

Background: The scapula osteocutaneous free flap is frequently used to reconstruct complex head and neck defects given its tissue versatility. Because of minimal atherosclerotic changes in its vascular pedicle, this flap also may be used as a second choice when other osseous flaps are not available because of vascular disease at a preferred donor site.

Methods: We performed a retrospective chart review evaluating flap outcome as well as surgical and medical complications based upon the flap choice.

Changing failure patterns in oropharyngeal squamous cell carcinoma treated with intensity modulated radiotherapy and implications for future research.

Objective: Review the University of Iowa experience with intensity modulated radiation treatment (IMRT) in oropharyngeal squamous cell carcinoma.

Methods: From January 2000 to July 2004, 66 patients with oropharyngeal cancer were treated with IMRT, 62 with definitive IMRT and 4 postoperative IMRT. Three target volumes (CTV1, CTV2, and CTV3) were defined.

Management of the radial forearm free flap donor site with the vacuum-assisted closure (VAC) system.

Introduction: The radial forearm free flap is a popular reconstructive flap in modern head and neck surgery. Poor wound healing at the forearm donor site is common and frequently results in tendon exposure. The Vacuum-Assisted Closure (VAC) system (Kinetic Concepts Inc.

Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma--the University of Iowa experience.

Purpose: To review the University of Iowa experience with intensity-modulated radiotherapy (IMRT) in the treatment of head-and-neck squamous cell carcinoma.

Methods And Materials: From October 1999 to April 2004, 151 patients with head-and-neck squamous cell carcinoma were treated with IMRT for curative intent. One patient was lost to follow-up 2 months after treatment and therefore excluded from analysis.

The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment.

Purpose: The role of neck dissection after definitive radiation for head-and-neck cancer is controversial. We select patients for neck dissection based on postradiation therapy (post-RT), computed tomography (CT), and [18F] fluorodeoxyglucose positron emission tomography (FDG PET). We summarize the clinical outcomes of patients treated with this policy to further elucidate the role of FDG PET in decision making for neck dissection after primary radiotherapy.

Use of AlloDerm for coverage of radial forearm free flap donor site.

Objectives: To evaluate and discuss the role of acellular human dermal matrix (AlloDerm, LifeCell Corp., Branchburg, NJ) graft for coverage of radial forearm free flap donor site.

Study Design: Prospective, nonrandomized study.